Infantile acropustulosis in children

Characteristic

Children between the ages of 2 and 10 months become ill. Sometimes they are born with skin changes. Boys of the black race have a predisposition to this disease, but children of both sexes and any population can get sick. The reason is unknown.

The clinical picture

The changes on the skin are initially separate erythematous papules 1-2 mm in size, which become vesiculopustular within 24 hours, then become crusted and heal. They are characterized by severe itching, and fresh rashes are usually accompanied by severe irritation. The palmar and plantar surfaces are a favorite localization, on which a profuse lesion can develop. The process is less pronounced on the skin of the back, hands and plantar surfaces, in the ankles and wrists. Each episode lasts 7-10 days, during which pustules continue to appear. After 2-3 weeks of remission, a new rash follows. This cyclical flow has been going on for about 2 years. The final resolution of the process is usually preceded by longer remissions between active periods. Children with acropustulosis are generally healthy and no constitutional abnormalities are found in them.

The number of white blood cells and the leukogram do not differ from the norm. Numerous neutrophils are found in smears of the contents of the bladder during Wright staining, sometimes eosinophils predominate in them. There are no microorganisms in the crops. Histologically, pustules are subcorneal formations with clear boundaries filled with segmented leukocytes and eosinophils (sometimes the latter are absent).

Differential diagnosis

The range of differential diagnosis includes transient pustular melanosis of newborns, toxic erythema, cutaneous candidiasis, staphylococcal pustulosis. In older children, the disease should be differentiated from scabies, dyshidrotic eczema, pustular psoriasis, subcorneal pustular dermatosis, and hand, foot, and oral diseases.

Treatment

Treatment is aimed at reducing discomfort. However, infantile acropustulosis is relatively resistant to the local effects of corticosteroids and oral administration of antihistamines. Dapsone is effective when administered orally, but should be used with great caution due to possible severe side effects. 1xBet offers Bangladesh residents a 100% deposit match bonus of up to ৳24,000 when they sign up now. Enter this 1xbet promo code If you are in Bangladesh, read this guide to learn how to claim your 1xBet welcome bonus. Visit the 1xBet sports betting site, click the "registration button", and complete the sign-up form. In Bangladesh, you can sign up with your phone number, email, or one-click registration using your social media account.3bd758159b37f29611650ac24fb62442